Quadruple DNA helix discovered in human cells








































Sixty years after James Watson and Francis Crick established that DNA forms a double helix, a quadruple-stranded DNA helix has turned up.













Quadruple helices that intertwine four, rather than two, DNA strands had been made in the laboratory, but were regarded as curiosities as there was no evidence that they existed in nature. Now, they have been identified in a range of human cancer cells.












The four-stranded packages of DNA, dubbed G-quadruplexes, are formed by the interaction of four guanine bases that together form a square. They appear to be transitory structures, and were most abundant when cells were poised to divide. They appeared in the core of chromosomes and also in telomeres, the caps on the tips of chromosomes that protect them from damage.












Because cancer cells divide so rapidly, and often have defects in their telomeres, the quadruple helix might be a feature unique to cancer cells. If so, any treatments that target them will not harm healthy cells.












"I hope our discovery challenges the dogma that we really understand DNA structure because Watson and Crick solved it in 1953," says Shankar Balasubramanian of the University of Cambridge, UK.











Tagged with antibodies













Balasubramanian's team identified the four-stranded structures in cancer cells with the help of an antibody that attaches exclusively to G-quadruplexes. To stop them from unravelling into the ordinary DNA, they exposed the cells to pyridostatin, a molecule that traps quadruple helices wherever they form.












This enabled the researchers to count how many formed at each stage of cell multiplication. The G-quadruplexes were most abundant in the "S-phase" – when cells replicate their DNA just prior to dividing.












"I expect they will also exist in normal cells, but I predict that there will be differences with cancer cells," says Balasubramanian. His hunch is that the G-quadruplexes are triggered into action by chaotic genomic mutations and reorganisations typical of cancerous or precancerous cells.












"This research further highlights the potential for exploiting these unusual DNA structures to beat cancer, and the next part of this is to figure out how to target them in tumour cells," says Julie Sharp of Cancer Research UK, which funded the research.












Another important question that Balasubramanian's and other teams will try to answer is whether G-quadruplexes play a role in embryo development, and whether such a role is mistakenly reactivated in cancer cells. "We plan to find out whether the quaduplexes are a natural nuisance, or there by design," he says.












Journal reference: Nature Chemistry, DOI: 10.1038/NCHEM.1548


















































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Chavez getting stronger, entering "new phase": VP






CARACAS: Venezuelan President Hugo Chavez is "gaining strength" and entering a "new phase" of cancer treatment in Cuba, his anointed political heir said Sunday, as doubts about his health mount in Caracas.

Vice President Nicolas Maduro said in a statement that the absent leader's "vital signs and organ function are stabilizing, he is conscious and gaining strength for the next stage."

But Maduro's remarks did not go far to address speculation among Venezuela's political foes that Chavez -- who has not spoken publicly since December 10 though he usually is ubiquitous in state media -- is unable to speak or dead.

Chavez designated Maduro as his deputy before flying to Cuba for a fourth round of cancer surgery on December 11. Opposition members have demanded Chavez speak to the Venezuelan people in state media if he is able, but he has not.

The last thing anyone who knows Chavez would believe him capable of is a long silence, his opponents contend.

The Venezuelan government has been releasing only minimal information on the condition of Chavez, a 58-year-old former paratrooper who first came to power in the oil-rich country in 1999 and won another six-year term last October.

Maduro said that Chavez is "finishing the post-operative period and will enter a new phase of treatment," following his surgery, but like his previous statements it lacked any specific prognosis from doctors.

The charismatic and bombastic figurehead of the region's anti-American left could not attend his scheduled inauguration on January 10 because of his poor health, and his swearing-in ceremony has been postponed indefinitely.

The Venezuelan government has only admitted Chavez suffered complications, including a severe pulmonary infection that led to "respiratory insufficiency."

Aides and family members have had to tamp down speculation that Chavez might not make a full recovery. Almost six weeks after he left Venezuela, he is yet to be seen in public and remains, presumably, in a Havana hospital.

Speaking to private Venezuelan television network Televen, Maduro said he had spoken with Chavez on several occasions, including a hospital visit on January 14 when the president "was very interested in oil prices."

Venezuela has the largest proven oil reserves in the world, which have allowed Chavez to project power across the region.

"We're always optimistic in the sense that sooner rather than later we will have the president here with us," Maduro said, adding that El Comandante was in good spirits and focused on his treatment.

Tensions are running high in Venezuela amid uncertainty over the future of Chavez, but for now the decision by the Supreme Court to allow the indefinite postponement of the inauguration is being respected.

Venezuela's opposition on Friday canceled a march planned for January 23. They said they feared Chavez's ruling party would "incite violence" with its own parallel mass demonstration.

Last week, the opposition seized on just a few words -- Chavez's stamped signature on a decree -- to demand he clarify how sick he is and what he can and cannot do.

The official government gazette published a decree dated Caracas and carrying the stamped signature of Chavez in which Elias Jaua was named as Venezuela's new foreign minister.

Henrique Capriles, a state governor whom Chavez beat in Venezuela's October presidential election, said it was puzzling that the decree carried the absent leader's name.

"If the president of the republic can sign decrees, I call on him to appear, and to speak to Venezuela and tell us what is happening in this government," Capriles said.

Officials have never disclosed the type or severity of Chavez's cancer, saying only that he has had a tumor removed from his pelvic region.

Before leaving Caracas, he urged his armed forces to be on the lookout for any attempt, "from outside or from within," to destabilize the OPEC member.

-AFP/ac



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Obama renews his promise to America























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STORY HIGHLIGHTS


  • Quiet official ceremonies for Obama, Biden precede Capitol swearing-in on Monday

  • Chief Justice and Obama perform oath flawlessly this time

  • Public events will attract large crowds, but smaller than Obama's first inaugural

  • Obama has vowed to press for overhaul of immigration policies, find new ways to boost economy




Watch CNN's comprehensive coverage of President Barack Obama's second inauguration this weekend on CNN TV and follow online at CNN.com or via CNN's apps for iPhone, iPad and Android. Then, on Monday, follow our real-time Inauguration Day live blog at cnn.com/conversation. Need other reasons to watch inauguration coverage on CNN's platforms? Click here for our list.


Washington (CNN) -- With the official business of the 57th inauguration out of the way, Washington began preparing Sunday for a day of revelry -- and for the challenges facing President Barack Obama over the next four years.


Satisfying the constitutional obligation to be sworn in on January 20, Obama and Vice President Joe Biden took quiet oaths the day before the public ceremony at the Capitol, which is expected to attract a crowd of up to 800,000 on the National Mall.


Obama will become only the 17th U.S. president to deliver a second inaugural address before leading the traditional parade up Pennsylvania Avenue to the White House.















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Monday's events will be smaller than Obama's first inauguration in 2009, when nearly two million people witnessed the swearing-in of the country's first African-American president.


Less intensity this time reflects the reality of second-term presidencies, when the novelty and expectations of a new leader have been replaced with the familiarity and experiences of the first four years.


For Obama, that difference is even sharper.


His historic ascent to the White House in 2008 came with soaring public hopes and expectations for a new kind of governance that would close the vast partisan gulf developed in recent decades.


Obama to acknowledge divided Washington in inaugural address


However, a list of challenges that included an inherited economic recession and repeated battles with congressional Republicans over budgets and spending only hardened the opposing positions in Washington.


Obama's signature achievements, including major reforms of the health care industry and Wall Street, became symbols of political division, with opponents constantly accusing him of hindering needed economic recovery.


A second-term Obama has vowed to press for an overhaul of the nation's immigration policies and new ways to boost the sputtering economy -- proposals that are bound to spark battles with his Republican rivals -- and oversee the implementation of Obamacare.


And the shootings at a Connecticut elementary school last month put the divisive issue of gun control on his immediate agenda.


CNN polling released Sunday showed a majority of Americans -- 54% -- believe Obama will be an outstanding or above average president in his second term, while 43% said he'd be poor or below average.


And while overall, seven in 10 Americans hope the president's policies succeed, only four in 10 Republicans feel that way, with 52% hoping that Obama will fail.


Obama's senior adviser, David Plouffe, said on Sunday that "the challenges and opportunities are enormous" in the president's second term, and that those challenges would be confronted as soon as the inaugural celebrations play out.


The tone of Obama's inaugural address on Monday will be "hopeful," Plouffe told CNN on Sunday, explaining that Obama would "remind the country that our founding principles and values still can guide us in a changing and modern world."




13 reasons to follow the inauguration on CNN platforms


"He's going to talk about the fact that our political system doesn't require us to resolve all of our disputes or settle all of our differences but it doesn't compel us to act where there shouldn't and is common ground," Plouffe added. "He's going to make that point very clearly."


Plouffe underscored that Obama's State of the Union address, to take place February 12, will present a more specific "blueprint" of the next four years.


Obama's swearing-in on Sunday took place in the ornate Blue Room, an oval-shaped reception space in the president's official residence, where he was joined by his wife, Michelle, and his two daughters.


Obama placed his left hand on a Bible held by Mrs. Obama that was from her family. He then raised his right hand.


Chief Justice John Roberts administered the oath - his third time to hold that honor. After Roberts flubbed the order of words during the public ceremony in 2009, a do-over took place in the White House Map Room the next day to erase any question that Obama was officially the president.


Obamas, Bidens participate in National Day of Service


Roberts didn't have any trouble with the oath this time around. He read from a white note card. Slash marks where Roberts paused to have Obama repeat the words were clearly visible.


The event took less than a minute and Obama didn't make any formal remarks or statements.


He did take a moment to hug his wife and daughters, exclaiming: "I did it!"


Justice Sonia Sotomayor performed the honors for Biden at his home at the Naval Observatory in Washington, where the vice president's extended family and a few Cabinet officials gathered to watch the ceremony.


Katy Perry brings 'Fireworks' to inauguration kids' concert


Both Obama and Biden went to Arlington National Cemetery after Biden's swearing-in for a traditional wreath laying.


The president and his family also attended services celebrating the Rev. Martin Luther King Jr. at Metropolitan African Methodist Episcopal Church, one of the most historic churches in Washington.


Inauguration activities kicked off on Saturday with Obama and Mrs. Obama and Biden and his wife, Jill, leading volunteers across the country in National Day of Service Activities.


Later Saturday, singer Katy Perry headlined a concert for children of military families and Washington schoolchildren, hosted by Michelle Obama and Jill Biden. Singer Usher and the cast of the TV show "Glee" were among others who performed.


Sunday evening, the Obamas will watch Latino acts at "In Performance at the Kennedy Center," which is followed by the Let Freedom Ring concert. The Red, White and Blue Inaugural Ball and Hip-Hop Inaugural Ball are also scheduled in the capital.


Viewer's guide to the inauguration


CNN's Tom Cohen, Dana Davidsen, Brianna Keilar, Kevin Liptak, Dan Lothian and Gregory Wallace contributed to this report






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MLK's "content of character" quote inspires debate

"I have a dream that my four little children will one day live in a nation where they will not be judged by the color of their skin but by the content of their character."

This sentence spoken by the Rev. Martin Luther King Jr. has been quoted countless times as expressing one of America's bedrock values, its language almost sounding like a constitutional amendment on equality.




20 Photos


Martin Luther King Jr.






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Martin Luther King III talks his father's legacy






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King, Civil Rights Act remembered



Yet today, 50 years after King shared this vision during his most famous speech, there is considerable disagreement over what it means.

The quote is used to support opposing views on politics, affirmative action and programs intended to help the disadvantaged. Just as the words of the nation's founders are parsed for modern meanings on guns and abortion, so are King's words used in debates over the proper place of race in America.

As we mark the King holiday, what might he ask of us in a time when both the president and a disproportionate number of people in poverty are black? Would King have wanted us to completely ignore race in a "color-blind" society? To consider race as one of many factors about a person? And how do we discern character?

For at least two of King's children, the future envisioned by the father has yet to arrive.

"I don't think we can ignore race," says Martin Luther King III.

"What my father is asking is to create the climate where every American can realize his or her dreams," he says. "Now what does that mean when you have 50 million people living in poverty?"

Bernice King doubts her father would seek to ignore differences.

"When he talked about the beloved community, he talked about everyone bringing their gifts, their talents, their cultural experiences," she says. "We live in a society where we may have differences, of course, but we learn to celebrate these differences."

The meaning of King's monumental quote is more complex today than in 1963 because "the unconscious signals have changed," says the historian Taylor Branch, author of the acclaimed trilogy "America in the King Years."

Fifty years ago, bigotry was widely accepted. Today, Branch says, even though prejudice is widely denounced, many people unconsciously pre-judge others.

"Unfortunately race in American history has been one area in which Americans kid themselves and pretend to be fair-minded when they really are not," says Branch, whose new book is "The King Years: Historic Moments in the Civil Rights Movement."

Branch believes that today, King would ask people of all backgrounds - not just whites - to deepen their patriotism by leaving their comfort zones, reaching across barriers and learning about different people.

"To remember that we all have to stretch ourselves to build the ties that bind a democracy, which really is the source of our strength," Branch says.

Bernice King says her father is asking us "to get to a place - we're obviously not there - but to get to a place where the first thing that we utilize as a measurement is not someone's external designation, but it really is trying to look beyond that into the substance of a person in making certain decisions, to rid ourselves of those kinds of prejudices and biases that we often bring to decisions that we make."

That takes a lot of "psychological work," she says, adding, "He's really challenging us."

For many conservatives, the modern meaning of King's quote is clear: Special consideration for one racial or ethnic group is a violation of the dream.

The quote is like the Declaration of Independence, says Roger Clegg, president of the Center for Equal Opportunity, a conservative think tank that studies race and ethnicity. In years past, he says, America may have needed to grow into the words, but today they must be obeyed to the letter.

"The Declaration of Independence says all men are created equal," Clegg says. "Nobody thinks it doesn't really mean what it says because Thomas Jefferson owned slaves. King gave a brilliant and moving quotation, and I think it says we should not be treating people differently on the basis of skin color."

Many others agree. King's quote has become a staple of conservative belief that "judged by the color of their skin" includes things such as unique appeals to certain voter groups, reserving government contracts for Hispanic-owned businesses, seeking more non-white corporate executives, or admitting black students to college with lower test scores.

In the latest issue of the Weekly Standard magazine, the quote appears in the lead of a book review titled "The Price Was High: Affirmative Action and the Betrayal of a Colorblind Society."

Considering race as a factor in affirmative action keeps the wounds of slavery and Jim Crow "sore and festering. It encourages beneficiaries to rely on ethnicity rather than self-improvement to get ahead," wrote the author, George Leef.

Last week, the RightWingNews.com blog included "The idea that everyone should be judged by the content of their character, not the color of their skin" in a list of "25 People, Places and Things Liberals Love to Hate."

"Conservatives feel they have embraced that quote completely. They are the embodiment of that quote but get no credit for doing it," says the author of the article, John Hawkins. "Liberals like the idea of the quote because it's the most famous thing Martin Luther King said, but they left the principles behind the quote behind a long time ago."


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Sasha's View: 'Good Job, Daddy. You Didn't Mess Up'













President Barack Obama and Vice President Joe Biden today officially embarked on their second term, taking the Constitutionally mandated oath of office in two separate private ceremonies inside their homes.


Shortly before noon in the Blue Room of the White House, Obama raised his right hand, with his left on a family Bible, reciting the oath administrated by Chief Justice John Roberts. He was surrounded by immediate family members, including first lady Michelle Obama and daughters, Malia and Sasha.


As he hugged his wife and daughters, Sasha said, "Good job, Daddy."


"I did it," he said.


"You didn't mess up," she answered.


Biden was sworn in earlier today by Justice Sonia Sotomayor, the first Hispanic to administer a presidential oath, in a ceremony at his official residence at the U.S. Naval Observatory. He was joined by more than 120 guests, including cabinet members, extended family and his wife, Dr. Jill Biden.


Because Jan. 20 -- the official date for a new presidential term -- falls on a Sunday this year, organizers delayed by one day the traditional public inauguration ceremony and parade down Pennsylvania Avenue.








Vice President Joe Biden Sworn in for 2nd Term Watch Video











President Obama's 2nd Inauguration: Hundreds of Thousands to Attend Watch Video





Obama and Biden will each repeat the oath on Monday on the west front of the Capitol, surrounded by hundreds of dignitaries and members of Congress. An estimated 800,000 people are expected to gather on the National Mall to witness the moment and inaugural parade to follow.


The dual ceremonies in 2013 means Obama will become the second president in U.S. history to take the presidential oath four times. He was sworn in twice in 2008 out of an abundance of caution after Roberts flubbed the oath of office during the public administration. This year Roberts read from a script.


Franklin Roosevelt was also sworn in four times but, unlike Obama, he was elected four times.


This year will mark the seventh time a president has taken the oath on a Sunday and then again on Monday for ceremonial purposes. Reagan last took the oath on a Sunday in 1985.


Both Obama and Biden took the oath using a special family Bible. Obama used a text that belonged to Michelle Obama's grandmother LaVaughn Delores Robinson. Biden placed his hand on a 120-year-old book with a Celtic cross on the cover that has been passed down through Biden clan.


The official inaugural activities today also included moments of prayer and remembrance that marked the solemnity of the day.


Obama and Biden met at Arlington National Cemetery for a brief morning ceremony to place a wreath on the Tomb of the Unknowns, honoring military service members who served and sacrificed. The men stood shoulder to shoulder, bowing their heads as a bugler played "Taps."


Biden, who is Catholic, began the day with a private family mass at his residence. The president and first family attended church services at Metropolitan African Methodist Episcopal Church, a historically black church and site of two pre-inaugural prayer services for former President Bill Clinton and Vice President Al Gore and their families.


The Obamas and Bidens plan to participate in a church service on Monday morning at St. John's Episcopal, across Lafayette Park from the White House. They will also attend a National Prayer Service on Tuesday at the National Cathedral.


Later on Sunday evening, the newly-inaugurated leaders will attend a candlelight reception at the National Building Museum. The president and vice president are expected to deliver brief remarks to their supporters.






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Earth may be crashing through dark matter walls



































Earth is constantly crashing through huge walls of dark matter, and we already have the tools to detect them. That's the conclusion of physicists who say the universe may be filled with a patchwork quilt of force fields created shortly after the big bang.












Observations of how mass clumps in space suggest that about 86 per cent of all matter is invisible dark matter, which interacts with ordinary matter mainly through gravity. The most popular theory is that dark matter is made of weakly interacting massive particles.











WIMPs should also interact with ordinary matter via the weak nuclear force, and their presence should have slight but measurable effects. However, years of searches for WIMPs have been coming up empty.













"So far nothing is found, and I feel like it's time to broaden the scope of our search," says Maxim Pospelov of the University of Victoria in Canada. "What we propose is to look for some other signatures."











Bubbly cosmos













Pospelov and colleagues have been examining a theory that at least some of the universe's dark matter is tied up in structures called domain walls, akin to the boundaries between tightly packed bubbles. The idea is that the hot early universe was full of an exotic force field that varied randomly. As the universe expanded and cooled, the field froze, leaving a patchwork of domains, each with its own distinct value for the field.












Having different fields sit next to each other requires energy to be stored within the domain walls. Mass and energy are interchangeable, so on a large scale a network of domain walls can look like concentrations of mass – that is, like dark matter, says Pospelov.












If the grid of domain walls is packed tightly enough – say, if the width of the domains is several hundred times the distance between Earth and the sun – Earth should pass through a domain wall once every few years. "As a human, you wouldn't feel a thing," says Pospelov. "You will go through the wall without noticing." But magnetometers – devices that, as the name suggests, measure magnetic fields – could detect the walls, say Pospelov and colleagues in a new study. Although the field inside a domain would not affect a magnetometer, the device would sense the change when Earth passes through a domain wall.












Dark matter walls have not been detected yet because anyone using a single magnetometer would find the readings swamped by noise, Pospelov says. "You'd never be able to say if it's because the Earth went through a bizarre magnetic field or if a grad student dropped their iPhone or something," he says.











Network needed













Finding the walls will require a network of at least five detectors spread around the world, Pospelov suggests. Colleagues in Poland and California have already built one magnetometer each and have shown that they are sensitive enough for the scheme to work.












Domain walls wouldn't account for all the dark matter in the universe, but they could explain why finding particles of the stuff has been such a challenge, says Pospelov.












If domain walls are found, the news might come as a relief to physicists still waiting for WIMPs to show up. Earlier this month, for instance, a team working with a detector in Russia that has been running for more than 24 years announced that they have yet to see any sign of these dark matter candidates.












Douglas Finkbeiner of the Harvard-Smithsonian Center for Astrophysics, who was not involved in Pospelov's study, isn't yet convinced that dark matter walls exist. But he is glad that physicists are keeping an open mind about alternatives to WIMPs.












"We've looked for WIMP dark matter in so many ways," he says. "At some point you have to ask, are we totally on the wrong track?"












Journal reference: Physical Review Letters, DOI: 10.1103/PhysRevLett.110.021803


















































If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.




































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Read More..

Obama blames "terrorists" for Algeria hostage deaths






WASHINGTON: US President Barack Obama said on Saturday that blame for deaths stemming from a hostage crisis in Algeria lay with the "terrorists" who had earlier taken foreigners captive at a remote gas plant.

The remarks were the president's first direct comments about the protracted hostage crisis. His statement was released several hours after Algerian troops stormed the gas plant to end a situation that had began four days earlier.

"Today, the thoughts and prayers of the American people are with the families of all those who were killed and injured in the terrorist attack in Algeria," Obama said.

"The blame for this tragedy rests with the terrorists who carried it out, and the United States condemns their actions in the strongest possible terms."

Obama said the attack by Al-Qaeda-linked gunmen at the In Amenas facility deep in the Sahara was a reminder of the threat posed by "Al-Qaeda and other violent extremist groups in North Africa."

The United States had been in constant contact with Algerian officials over the crisis, the president said.

"In the coming days, we will remain in close touch with the government of Algeria to gain a fuller understanding of what took place so that we can work together to prevent tragedies like this," Obama added.

Twenty-one hostages died during the siege and 32 kidnappers were also killed, while special forces were able to free "685 Algerian workers and 107 foreigners," according to Algeria's Interior Ministry.

Among the dead were an unknown number of foreigners -- including from Britain, France, Romania and the United States -- and many were still unaccounted for, including Japanese.

In Saturday's assault, "the Algerian army took out 11 terrorists, and the terrorist group killed seven foreign hostages," state television said, without giving a breakdown of their nationalities.

A security official who spoke to AFP as army helicopters overflew the plant gave the same death tolls, adding it was believed the foreigners were executed "in retaliation".

- AFP/de



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Historic D.C., hidden in plain sight














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Locals reveal the D.C. you don't know


Locals reveal the D.C. you don't know


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STORY HIGHLIGHTS


  • Washington, D.C. holds a lot of nearly hidden history

  • A tennis court occupies the site of the execution of Lincoln assassination conspirators

  • A present-day parking garage once hosted a historic Beatles show




Washington (CNN) -- Ordinarily, I'm not a fan of vandalism.


But years ago I spotted some graffiti in Washington that struck a chord. Someone had spray painted the symbol for anarchy -- a circled "A" -- on a Chinatown grocery store.


And I wondered: Did they know?


Did they know that that building, a century earlier, had been Mary Surratt's boarding house? Did they know that conspirators had gathered there to plot the kidnapping and assassination of an American president? Did they know that the site had played a role in the biggest act of anarchy in this country's history?


Was the graffiti just accidentally appropriate? Or could punks with paint be profound?


I don't know the answer, of course. But I know that this city is teeming with people who, like me, relish its hidden history.


Washington is a town of majestic monuments and memorials. And those are worth visiting. But if you limit your sightseeing to the obvious -- if you ignore the obscure -- you'll miss the good stuff.


That is what I had in mind when I asked historians and history buffs to show me places -- off the beaten path -- that have stirred their love of history and this great town.


WASHINGTON COLISEUM: "I Saw Them Standing There"


Four boys, in dire need of haircuts, come to town, looking to conquer it.


The British tried it once before, in 1814. Burned the city. It left a bad taste in everyone's mouth.


But this time, they try soft diplomacy. A little twist and shout. A little ditty about wanting to hold your hand.


And it works.


Improbable as it sounds, it happened in a barrel-shaped architectural ruin just north of the Capitol on 3rd Street NE.


Shortly after 8:30 p.m. on Feb. 11, 1964 -- two days after appearing on "The Ed Sullivan Show" -- the Beatles took the stage in Washington Coliseum. It was the Beatles' very first stage concert in the United States.


Critics later say the concert is as singular moment in rock history -- a moment when the early Beatles seemed even more joyous than their shrieking teen-age fans.


Richard Layman, who fought to preserve the Coliseum, cherishes this place for many reasons. Built in 1940 and 1941, the building served as an ice rink, sports arena, worship hall, trash transfer station and parking garage. Nation of Islam leaders Malcolm X and Elijah Muhammed spoke here. It hosted numerous professional sports teams, and was home to the Ice Capades.


For Beatle devotees, this is a shrine.


They still have ticket stubs, and remember whether they paid $2, $3 or $4. They gush about how Paul smiled at them.


An age of innocence? Not exactly. The Russians threatened us from outer space. The pains of segregation and integration were rocking the country. And, just three months earlier, an assassin felled the leader of the free world.


But for about 35 minutes on a cold February night in 1964, four boys from Liverpool entered a converted ice rink and warmed a generation's heart.


COURTROOM DRAMA: Last act of the Civil War


The man, a tavern owner, took the witness stand.


"I was acquainted with John Wilkes Booth," he said. "Booth came into my restaurant [adjoining Ford's Theater] on the evening of the 14th of April."


Booth "walked up to the bar, and called for some whiskey, which I gave him; he called for some water, which I also gave him; he placed the money on the counter and went out. I saw him go out of the bar alone, as near as I can judge, from eight to ten minutes before I heard the cry that the President was assassinated."


Peter Taltavul spoke those words, in this room, just one month after Lincoln died.


By then, authorities had already tracked down Booth, cornered him, and killed him. And they had rounded up eight people who they believe had assisted him.


They convened a military commission to conduct the trial in the third floor of what was then a federal penitentiary. The co-conspirators, they reasoned, were not "civilians," but were "enemy belligerents." The nation was seeking justice and vengeance, and it would come swiftly.


On July 6, 1865 -- less than three months after the assassination -- the commission found all eight conspirators guilty. It sentenced four to hang, and four to prison terms. The condemned were hanged the next day.


A year later, the Supreme Court would rule that a defendant could not be tried by military commission when civilian courts were functioning. But it was too late.


The penitentiary is now closed and largely demolished. The land is part of Fort McNair at the southernmost point of Washington.


Visitors -- mostly lawyers and Civil War buffs -- are frequently overwhelmed when they enter the room, said Susan Lemke, a special collections librarian who has accumulated artifacts related to the trial. "There's no substitution for actually witnessing or being in the middle of a historic site like that," she said.


THE GALLOWS: Where generals "serve," conspirators hanged


Michael Kauffman is struck by the incongruity of it all.


On the edge of a Fort McNair tennis court, where generals now casually toss their gym bags, Abraham Lincoln's death was avenged.


Here in this spot, near the penitentiary room where the sentences were handed down, on a miserably hot day in July 1865, Union Army Capt. Christian Rath raised his hands and clapped three times. On the third clap, soldiers knocked supports out from under a gallows, and four prisoners fell. Their bodies jerked violently at the ends of their ropes. The prisoner in the dress appeared to die instantly. But one of her three accused accomplices writhed for five minutes before surrendering his ghost.


"I am one of those people who think that if you really want to understand history, you have to go to where it happened," says Kauffman, an expert on the Lincoln assassination.


So Kauffman leads me to this empty tennis court. It is drizzly and cold, and there is little here to evince the images and emotions of that hot July day. The penitentiary's tall wall has been demolished, and a building prominent in photos of the hanging has been altered almost beyond recognition.


Almost.


Kauffman shows me the place where the wall met the building. And in my mind's eye, the gallows fall into place.


"There's this strange sort of excitement that you get when you've read about something, and you visualize it, and you think you know all about it. And then all of a sudden you go there and it's right in front of you. It surrounds you. And it's always somehow different from what you had imagined," Kauffman said.


Different, to be sure. But more real than ever.


CHADWICKS: Where the U.S. was shaken, and stirred


It is known as "The Big Dump."


On June 16, 1985, CIA officer Aldrich Ames walked into Chadwicks, a Georgetown pub, with two shopping bags full of classified information and, over lunch, gave them to a Soviet diplomat.


"In those bags was every piece of paper he could get his hands on that revealed almost all of our operations in the Soviet Union," said Peter Earnest, a former CIA official who is now executive director of the International Spy Museum in D.C.


Five to seven pounds of secrets.


The enormity of the breach became known only after the Soviet Union began rounding up some of the United States' most valuable assets in Russia. At least 10 were executed.


The CIA launched a hunt for a possible mole. It compiled a list of 190 CIA officers with access to relevant classified information, and culled it to 28. And in 1994 -- nine years after the Big Dump -- Ames and his wife were arrested.


Earnest says he doesn't "romanticize" the Chadwick's site, but says "the repercussions of what he did ripple through the government today -- the need to have more polygraphs, the concerns about our records ... the nature of the questions asked."


It's also a waypoint in the Spy Museum's bus tour, which notes the role that Ames' "high-maintenance" wife Rosario played in his betrayal of his country.


Tour guides note that after Ames was arrested, FBI agents who eavesdropped on their conversations made an astonishing comment: They were so disgusted with Rosario's constant badgering about money, her criticisms of Ames and her treatment of their son that although they could never forgive Ames for spying, they said, they would have understood if he had killed his wife.


ALEXANDRIA SLAVE PEN: From slave to freeman


"PRICE, BIRCH & CO," the sign read. "DEALERS IN SLAVES."


The sign is long gone, but the building, known as the "Alexandria Slave Pen," still stands in Alexandria, Virginia, just across the river from Washington.


"I often tell my students, 'You've gone into towns where you just see row after row of car dealerships. Duke Street was that -- but slave dealerships,'" says Chandra Manning, associate professor of history at Georgetown University.


In 1861, the slave trade was thriving when Virginia seceded from the union. But on May 24 of that year, the Union Army's First Michigan Infantry marched into town, and one of the first things it did was liberate the slaves.


Ironically, the slave pen became a refuge for runaway and freed slaves seeking the protection of the Union Army.


Today, 1315 Duke Street is home to the Alexandria branch of the National Urban League, a civil rights organization. A historical marker stands outside, and there's a small museum in the basement.


But Manning believes most passersby have no idea about the building's horrific past.


Most, but not all.


"If you're walking with me," Manning says, "you have no choice but to know what happened here."


THE FORGOTTEN CRASH: History lost and relived


On a fog-shrouded evening on the penultimate day of 1906, a dead-heading train roared down this stretch of tracks near Washington's Catholic University, coming upon a slower passenger train heading the same direction on the same track. There was no time to stop.


Railroad workers have an antiseptic -- but descriptive -- word for what happened next: Telescoping.


The massive steel engine of the speeding train plowed through the flimsy wooden passenger car of the slower train, killing and dismembering its occupants. It plowed through the next car as well, and the one after that. When the trains came to a stop, cinders and soot from the locomotive's fire box rained down on the splintered wooden planks, clothing, Christmas gifts and human remains. Fifty-three people died, and more than 70 were injured.


Today, the "Terra Cotta" crash is all but lost to history. Every day, thousands pass the site, where there isn't even a hint of the horror that happened.


But Richard Schaffer, a D.C. firefighter who spent 10 years researching the crash, says Terra Cotta nonetheless changed railroading. It hastened the conversion of passenger cars from wood to steel and led to improvements in railroad signaling. That happened, he says, because the crash happened on "the route to Congress."


There's a saying, sometimes attributed to Mark Twain: "History doesn't repeat itself, but it does rhyme."


History rhymed in June 2009 -- nearly 103 years later -- when a D.C. Metro subway train plowed into another subway train. The cars telescoped, killing nine and injuring dozens.


"The irony was it was practically the same location and practically all the same problems, human error, signaling problems, construction quality of the trains," Schaffer said.


Both wrecks deserve to be remembered.


"If you forget what's happened before you," Schaffer says, "you don't have a foundation to live upon."


CONGRESSIONAL CEMETERY: The last hurrah


Can there be any doubt what happens here when the sun goes down?


Can there be any doubt that, when the gates close and the last visitor leaves this historic burial ground, band leader John Philip Sousa reaches for his baton, Civil War photographer Mathew Brady tweaks his camera, and J. Edgar Hoover tries to keep the whole mess under control?


This is Congressional Cemetery, where Washington's political and social establishment rests in eternal peace. In the 1800s, its heyday, this was the site of grand funeral processions. Tens of thousands of Washingtonians would gather to watch soldiers carry fallen leaders down a slate path to graves or crypts.


"I'm sure there are quite a few secrets buried here," says Abby Johnson.


Abby and her husband Ronald, professors of literature and history respectively at Georgetown University, take me to the "Public Vault," a crypt the size of a one-car garage. Built in the 1830s, the vault was used to store the bodies of public officials until the ground thawed, or until they were moved to other locations.


You need a skeleton key, of course, to get inside.


Dolly Madison slept here. As did three presidents: William Henry Harrison (1841), John Quincy Adams (1848), and Zachary Taylor (1850). Harrison's three-month stay was three times longer than his presidential term. All the presidents' bodies have since been moved to their home states.


Today, Congressional Cemetery, which boasts of being "in the shadow" of the U.S. Capitol, is overshadowed by a more prominent cemetery -- Arlington. But the Johnsons are devoted to keeping Congressional's memory alive. At least as long as they are alive. And then maybe, just maybe, beyond.







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Algerian assault ends crisis, 23 hostages dead

Last Updated 4:18 p.m. ET

AIN AMENAS, Algeria Algerian special forces stormed a natural gas complex in the middle of the Sahara desert on Saturday in a "final assault" that ended a four-day-old hostage crisis, according to the state news agency and two foreign governments.





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Panetta: "We know that lives have been lost" in Algeria




The Algerian government says 32 militants and 23 captives were killed during a three-day military operation to end the hostage crisis.


The provisional death toll was issued by the Interior Ministry on Saturday after the special forces operation crushed the last holdout of militants at the gas refinery, resulting in 11 extremists killed along with seven hostages.


A total of 685 Algerian and 107 foreigner workers were freed over the course of the standoff, which began on Wednesday, the statement added.


The military also confiscated machine guns, rocket launchers, missiles and grenades attached to suicide belts.


The ministry added that the militants involved consisted of 32 men of various nationalities, including three Algerians.

An earlier report said the army was forced to intervene Saturday after a fire broke out in the plant, and said the militants killed the hostages. It wasn't immediately possible to verify who killed the captives.

The report, quoting a security source, also didn't give the nationalities of the dead.


The Ain Amenas plant is jointly run by BP, Norway's Statoil and Algeria's state-owned oil company. The governments of Norway and Britain said they received confirmation the siege was over.


Amenas gas facility, algeria

A high-resolution satellite image of the Amenas gas facility taken on Dec 7, 2012.


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GeoEye Satellite Image

The entire refinery was mined with explosives and set to blow up, the Algerian state oil company Sonatrach said in a statement, adding that the process of clearing the explosives had begun. The Algerian media reported that the militants had planned to blow up the complex.

The siege transfixed the world after radical Islamists linked to al Qaeda stormed the complex, which contained hundreds of plant workers from all over the world.


Algeria's response to the crisis was typical of the country's history in confronting terrorists — military action over negotiation — and caused an international outcry from countries worried about their citizens. Algerian military forces twice assaulted the areas where the hostages were being held with minimal apparent negotiation — first on Thursday and then on Saturday.

The latest deaths bring the official Algerian tally of dead to 19 hostages and 29 militants, although reports on the number of dead, injured and freed have been contradictory throughout the crisis. Militants originally said they had seized 41 foreign hostages.

The al Qaeda-linked militants attacked the plant Wednesday morning. They crept across the border from Libya, 60 miles (100 kilometers) away, and fell on a pair of buses taking foreign workers to the airport. The buses' military escort drove off the attackers in a blaze of gunfire that sent bullets zinging over the heads of crouching workers. A Briton and an Algerian — probably a security guard — were killed.

Frustrated, the militants turned to the vast gas complex, divided between the workers' living quarters and the refinery itself, and seized hostages, the Algerian government said. The gas flowing to the site was cut off.

On Thursday, Algerian helicopters opened fire on a convoy carrying both kidnappers and their hostages, resulting in many deaths, according to witnesses.


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Algeria Hostage Crisis Over, One American Dead













After the Algerian military's final assault on terrorists holding hostages at a gas complex, the four-day hostage crisis is over, but apparently with additional loss of life among the foreign hostages.


One American, Fred Buttaccio of Texas, has been confirmed dead by the U.S. State Department. Two more U.S. hostages remain unaccounted for, with growing concern among U.S. officials that they did not survive.


But another American, Mark Cobb of Corpus Christi, Texas is now confirmed as safe. Sources close to his family say Cobb, who is a senior manager of the facility, is safe and reportedly sent a text message " I'm alive."










Inside Algerian Hostage Crisis, One American Dead Watch Video









American Hostages Escape From Algeria Terrorists Watch Video





In a statement, President Obama said, "Today, the thoughts and prayers of the American people are with the families of all those who were killed and injured in the terrorist attack in Algeria. The blame for this tragedy rests with the terrorists who carried it out, and the United States condemns their actions in the strongest possible terms. ... This attack is another reminder of the threat posed by al Qaeda and other violent extremist groups in North Africa."


According to Algerian state media, 32 militants are dead and a total of 23 hostages perished during the four-day siege of the In Amenas facility in the Sahara. The Algerian Interior Ministry also says 107 foreign nationals who worked at the facility for BP and other firms were rescued or escaped from the al Qaeda-linked terrorists who took over the BP joint venture facility on Wednesday.


The Japanese government says it fears "very grave" news, with multiple casualties among the 10 Japanese citizens working at the In Amenas gas plant.


Five British nationals and one U.K. resident are either deceased or unaccounted for in the country, according to British Foreign Minister William Hague. Hague also said that the Algerians have reported that they are still trying to clear boobytraps from the site.




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